Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | AXL | P30530 | 5/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043036 | 0.89 | FLT3 (0.53) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL12780690 | 0.89 | FLT3 (0.53) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL12780688 | 0.89 | FLT3 (0.53) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL4043618 | 0.88 | FLT3 (0.57) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780687 | 0.81 | FLT3 (0.51) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL4041335 | 0.81 | FLT3 (0.51) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL4045933 | 0.78 | FLT3 (0.70) | FLT3KITAXLIRAK4JAK2 | |
| SCHEMBL4043415 | 0.78 | FLT3 (0.60) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780729 | 0.78 | FLT3 (0.60) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL13963948 | 0.77 | FLT3 (0.69) | FLT3KITAXLIRAK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |