Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040885 | 0.94 | GCGR (0.50) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4044047 | 0.93 | GCGR (0.51) | GCGRTP53NOS1NOS2MAPT | |
| SCHEMBL4042323 | 0.92 | GCGR (0.50) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4044917 | 0.92 | GCGR (0.46) | GCGRTP53MAPTNPSR1SAE1 | |
| SCHEMBL4037348 | 0.91 | GCGR (0.60) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4043997 | 0.91 | GCGR (0.49) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4044279 | 0.91 | GCGR (0.47) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4039698 | 0.91 | GCGR (0.47) | GCGRTP53MAPTNPSR1SAE1 | |
| SCHEMBL4039156 | 0.91 | GCGR (0.47) | GCGRTP53NOS3NOS1NOS2 | |
| SCHEMBL4039276 | 0.90 | GCGR (0.45) | GCGRTP53MAPTNPSR1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |