Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.66 |
| ▸ | HTR2C | P28335 | 17/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949986 | 0.91 | HTR2A (0.67) | HTR2AHTR2CTSHRMAPTL3MBTL1 | |
| SCHEMBL4148583 | 0.91 | HTR2A (0.58) | HTR2AHTR2CTSHRMAPTL3MBTL1 | |
| SCHEMBL3948069 | 0.91 | HTR2A (0.60) | HTR2AHTR2CTSHRSMN1; SMN2MAPT | |
| SCHEMBL3947397 | 0.86 | HTR2A (0.63) | HTR2AHTR2CTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3948352 | 0.86 | HTR2A (0.67) | HTR2AHTR2CTSHRMAPTL3MBTL1 | |
| SCHEMBL3950888 | 0.86 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL14384989 | 0.85 | HTR2A (0.55) | HTR2AHTR2CTSHRSMN1; SMN2MAPT | |
| SCHEMBL3953618 | 0.84 | HTR2A (0.68) | HTR2AHTR2C | |
| SCHEMBL3948224 | 0.84 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL4206004 | 0.82 | DRD4 (0.58) | HTR2AHTR2CTSHRMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |