Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.70 |
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | FLT1 | P17948 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044449 | 0.82 | KDR (1.00) | EGFRKDRFLT1FLT4ERBB2 | |
| SCHEMBL1220008 | 0.78 | ERBB2 (0.79) | EGFRKDRERBB2AAK1 | |
| SCHEMBL5511762 | 0.78 | KDR (0.79) | EGFRKDR | |
| SCHEMBL5739719 | 0.77 | KDR (0.57) | EGFRKDR | |
| SCHEMBL1220196 | 0.74 | EGFR (0.76) | EGFRKDRERBB2AAK1 | |
| SCHEMBL4047327 | 0.73 | KDR (0.68) | EGFRKDRFLT1FLT4 | |
| SCHEMBL18879040 | 0.72 | EGFR (0.57) | EGFRKDRFLT1FLT4ERBB2 | |
| SCHEMBL1461250 | 0.70 | KDR (0.76) | EGFRKDRFLT1FLT4 | |
| SCHEMBL6100171 | 0.69 | EGFR (0.75) | EGFRKDRFLT1FLT4ERBB2 | |
| SCHEMBL4047606 | 0.69 | KDR (0.74) | EGFRKDRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669071-B1 | Pyrrolotriazine inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-1669071-A1 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-06-14 | — | — | EP | disclosed |