Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123714 | 0.81 | NOTUM (0.55) | NOTUMCYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL2120380 | 0.79 | NOTUM (0.53) | NOTUMCYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL4037075 | 0.78 | NOTUM (0.55) | NOTUMSCN9ACYP2C9CYP2C19CYP2E1 | |
| SCHEMBL16482130 | 0.78 | S1PR1 (0.50) | SCN9ACYP2C9CYP2C19S1PR1CYP1A2 | |
| SCHEMBL2120898 | 0.76 | NOTUM (0.60) | NOTUMCYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL30093453 | 0.76 | S1PR1 (0.45) | SCN9ACYP2C9CYP2C19S1PR1CYP1A2 | |
| SCHEMBL28214769 | 0.75 | HCRTR1 (0.48) | SCN9ACYP2C9S1PR1CYP3A4CYP2D6 | |
| SCHEMBL4036299 | 0.75 | NTRK1 (0.40) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27612624 | 0.74 | NOTUM (0.62) | NOTUMCYP2C9CYP2C19CYP2E1CYP2A6 | |
| SCHEMBL1221395 | 0.74 | NPC1 (0.36) | SCN9ACYP2C9CYP2C19S1PR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |