Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.72 |
| ▸ | HTR2C | P28335 | 15/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947503 | 0.94 | HTR2A (0.81) | HTR2AHTR2C | |
| SCHEMBL4037245 | 0.93 | HTR2A (0.69) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3948351 | 0.93 | HTR2A (0.73) | HTR2AHTR2CKCNH2HSD17B10 | |
| SCHEMBL3954910 | 0.92 | HTR2A (0.69) | HTR2AHTR2C | |
| SCHEMBL4538316 | 0.92 | HTR2A (0.71) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1166010 | 0.91 | HTR2A (0.86) | HTR2AHTR2C | |
| SCHEMBL3945712 | 0.91 | HTR2A (0.77) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1166097 | 0.90 | HTR2A (0.69) | HTR2AHTR2CMAPTKCNH2 | |
| SCHEMBL4039931 | 0.90 | HTR2A (0.66) | HTR2AHTR2CMAPT | |
| SCHEMBL1166067 | 0.90 | HTR2A (0.75) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |