Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.35 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044716 | 0.87 | PDGFRB (0.47) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL4042554 | 0.82 | CHEK1 (0.51) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL4044113 | 0.81 | KMT2A (0.44) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL4045624 | 0.81 | PDGFRB (0.47) | PDGFRBCHEK1MEN1KMT2AGAA | |
| SCHEMBL4052115 | 0.81 | PDGFRB (0.47) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL4048672 | 0.79 | HIF1A (0.47) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL4044321 | 0.79 | EGFR (0.43) | PDGFRBCHEK1LMNAMEN1KMT2A | |
| SCHEMBL6247545 | 0.78 | PDGFRB (0.44) | PDGFRBCHEK1MEN1KMT2AMAPT | |
| SCHEMBL4041812 | 0.77 | PDGFRB (0.51) | PDGFRBCHEK1 | |
| SCHEMBL4041092 | 0.76 | PDGFRB (0.44) | PDGFRBCHEK1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | claimed |