SCHEMBL4043515

SCHEMBL4043515

CC(C)Oc1ccc([N+](=O)[O-])cc1OC(F)F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.55
KMT2A Q03164 6/20 0.46
MAPT P10636 6/20 0.46
MEN1 O00255 5/20 0.46
HTT P42858 3/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
RAB9A P51151 2/20 0.46
GAA P10253 1/20 0.46
XBP1 P17861 1/20 0.46
CCR6 P51684 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TDP1 Q9NUW8 1/20 0.44
GLA P06280 1/20 0.44
ALDH1A1 P00352 3/20 0.42
PDK1 Q15118 1/20 0.42
POLB P06746 1/20 0.41
CYP2D6 P10635 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2086886 1.00 CYP19A1 (0.55) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL8609293 0.92 MAPT (0.51) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL11835883 0.92 CYP19A1 (0.61) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL4326715 0.86 HTT (0.58) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL4323651 0.86 HTT (0.58) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL31081103 0.84 HTT (0.60) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL3820703 0.84 HTT (0.60) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL2372164 0.84 HTT (0.60) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL17593420 0.81 CYP19A1 (0.51) CYP19A1KMT2AMAPTMEN1HTT
SCHEMBL31506375 0.81 CYP19A1 (0.57) CYP19A1KMT2AMAPTMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2051788-A1 EXTRACTION PROCESS USING AN IONIC LIQUID Invista Technologies S.à.r.l. (CH) 2009-04-29 EP disclosed
EP-1562589-B1 DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES VERTEX PHARMA (US) 2009-01-07 EP disclosed
WO-2008022233-A1 EXTRACTION PROCESS USING AN IONIC LIQUID INVISTA TECHNOLOGIES S.A.R.L. (CH) 2008-02-21 WO disclosed