Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.34 |
| ▸ | GCK | P35557 | 2/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2989091 | 0.89 | EGFR (0.46) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL13206361 | 0.89 | EGFR (0.46) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL2994916 | 0.82 | EGFR (0.38) | EGFRERBB2GCKBRAFRAF1 | |
| SCHEMBL4035583 | 0.77 | EGFR (0.37) | EGFRCDK7BTKTP53 | |
| SCHEMBL2984085 | 0.76 | EGFR (0.51) | EGFRERBB2ERBB4 | |
| SCHEMBL2994908 | 0.71 | EGFR (0.50) | EGFRERBB2BRAFRAF1HTT | |
| SCHEMBL2994910 | 0.71 | EGFR (0.50) | EGFRERBB2BRAFRAF1HTT | |
| SCHEMBL2987644 | 0.70 | EGFR (0.61) | EGFRERBB2BRAFRAF1HTT | |
| SCHEMBL2985098 | 0.70 | EGFR (0.59) | EGFRERBB2ERBB4 | |
| SCHEMBL3324105 | 0.67 | EGFR (0.49) | EGFRGCKBRAFCDK7RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501427-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2009-03-10 | — | — | US | claimed |