Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.55 |
| ▸ | KIT | P10721 | 4/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780661 | 1.00 | FLT3 (0.55) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780659 | 1.00 | FLT3 (0.55) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL4036856 | 0.88 | FLT3 (0.54) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780600 | 0.87 | KIT (0.40) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780595 | 0.87 | KIT (0.40) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL4043796 | 0.84 | FLT3 (0.61) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780653 | 0.83 | FLT3 (0.52) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL4038317 | 0.83 | FLT3 (0.52) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780655 | 0.83 | FLT3 (0.52) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780668 | 0.82 | KIT (0.47) | FLT3KITIRAK4JAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |