⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685279 | 0.75 | — | — | |
| SCHEMBL10472607 | 0.75 | CA1 (0.43) | — | |
| SCHEMBL27281111 | 0.72 | — | — | |
| SCHEMBL2772640 | 0.70 | — | — | |
| Sulfamate SCHEMBL6757265 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL5155881 | 0.67 | — | — | |
| Sulfamate SCHEMBL22345885 | 0.67 | — | — | |
| Sulfuric Acid SCHEMBL10455785 | 0.64 | BLM (0.47) | — | |
| SCHEMBL73888 | 0.64 | — | — | |
| SCHEMBL6631948 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641801-B9 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORP (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1641801-B1 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| US-7368457-B2 | Bridged N-arylsulfonylpiperidines as gamma-secretase inhibitors | SCHERING CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1641801-A2 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004101562-A2 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040229902-A1 | Bridged N-arylsulfonylpiperidines as gamma-secretase inhibitors | SCHERING CORPORATION | 2004-11-18 | — | — | US | disclosed |