Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.43 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045095 | 0.92 | PDGFRB (0.64) | PDGFRBCHEK1ABL1LCKFYN | |
| SCHEMBL4045537 | 0.89 | PDGFRB (0.58) | PDGFRBCHEK1ABL1LCKFYN | |
| SCHEMBL4048239 | 0.88 | PDGFRB (0.58) | PDGFRBCHEK1ABL1LCKFYN | |
| SCHEMBL4052087 | 0.85 | CHEK1 (0.60) | PDGFRBCHEK1 | |
| SCHEMBL4045105 | 0.84 | PDGFRB (0.67) | PDGFRBCHEK1ABL1LCKFYN | |
| SCHEMBL4041860 | 0.84 | PDGFRB (0.65) | PDGFRBCHEK1EIF2AK1 | |
| SCHEMBL4043259 | 0.83 | PDGFRB (0.51) | PDGFRBCHEK1EIF2AK1 | |
| SCHEMBL3087060 | 0.81 | CHEK1 (0.54) | PDGFRBCHEK1 | |
| SCHEMBL4050743 | 0.81 | CHEK1 (0.54) | PDGFRBCHEK1 | |
| SCHEMBL4045920 | 0.81 | PDGFRB (0.65) | PDGFRBEIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | claimed |