Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4045725 | 1.00 | KCNH2 (0.41) | KCNH2TRPV3 | |
| Bicarbonate SCHEMBL4043287 | 1.00 | KCNH2 (0.41) | KCNH2TRPV3 | |
| SCHEMBL5264047 | 0.85 | KCNH2 (0.38) | KCNH2 | |
| SCHEMBL3579608 | 0.85 | KCNH2 (0.38) | KCNH2 | |
| SCHEMBL3581981 | 0.85 | KCNH2 (0.38) | KCNH2 | |
| SCHEMBL3573905 | 0.85 | KCNH2 (0.38) | KCNH2 | |
| Bicarbonate SCHEMBL5738279 | 0.81 | KCNH2 (0.40) | KCNH2 | |
| Bicarbonate SCHEMBL5738348 | 0.81 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL5262915 | 0.81 | KCNH2 (0.38) | KCNH2TRPV3 | |
| SCHEMBL5259010 | 0.81 | KCNH2 (0.38) | KCNH2TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |