Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.78 |
| ▸ | RAB9A | P51151 | 10/20 | 0.78 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.78 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.71 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096659 | 0.90 | NPC1 (0.66) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL1811300 | 0.88 | NPC1 (1.00) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL27790138 | 0.88 | NPC1 (0.80) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL24634686 | 0.87 | KDM4E (0.74) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL30876549 | 0.87 | KDM4E (0.74) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL4039804 | 0.85 | NPC1 (0.75) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL4037950 | 0.84 | NPC1 (0.85) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL27790128 | 0.84 | NPC1 (0.86) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL4035597 | 0.84 | NPC1 (0.86) | NPC1RAB9AHSP90AA1ALOX12POLB | |
| SCHEMBL2153766 | 0.84 | NPC1 (0.86) | NPC1RAB9AHSP90AA1ALOX12POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | claimed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | claimed |
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | disclosed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |