Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045373 | 0.91 | PDGFRB (0.47) | PDGFRBGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4046610 | 0.87 | PDGFRB (0.37) | PDGFRBKDM4ESRCEGFRABL1 | |
| SCHEMBL4046330 | 0.87 | LCK (0.37) | PDGFRBSRCEGFRABL1MEN1 | |
| SCHEMBL4041088 | 0.86 | EGFR (0.40) | PDGFRBGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4045418 | 0.84 | CHEK1 (0.36) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL4042472 | 0.84 | CHEK1 (0.33) | PDGFRBMEN1KMT2A | |
| SCHEMBL13146454 | 0.82 | MAPT (0.41) | PDGFRBALDH1A1KDM4EHPGDSRC | |
| SCHEMBL4047825 | 0.82 | MAPT (0.41) | PDGFRBALDH1A1KDM4EHPGDSRC | |
| SCHEMBL13146470 | 0.82 | MAPT (0.41) | PDGFRBALDH1A1KDM4EHPGDSRC | |
| SCHEMBL4042493 | 0.82 | PDGFRB (0.45) | PDGFRBGAAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |