Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 10/20 | 0.48 |
| ▸ | LYN | P07948 | 9/20 | 0.48 |
| ▸ | SRC | P12931 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 9/20 | 0.48 |
| ▸ | INSR | P06213 | 8/20 | 0.48 |
| ▸ | HCK | P08631 | 7/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967441 | 0.90 | MAPK14 (0.54) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL4044422 | 0.90 | MAPK14 (0.55) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3589946 | 0.89 | MAPK14 (0.53) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3580355 | 0.88 | MAPK14 (0.51) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3594987 | 0.87 | LCK (0.63) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3583316 | 0.87 | LCK (0.55) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3592111 | 0.86 | LCK (0.58) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL4044337 | 0.86 | MAPK14 (0.47) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL3597693 | 0.86 | LCK (0.52) | MAPK14LCKLYNSRCKDR | |
| SCHEMBL9967440 | 0.85 | MAPK14 (0.54) | MAPK14LCKLYNSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |