Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 9/20 | 0.52 |
| ▸ | MC4R | P32245 | 6/20 | 0.52 |
| ▸ | MC3R | P41968 | 6/20 | 0.52 |
| ▸ | NAMPT | P43490 | 5/20 | 0.48 |
| ▸ | MC1R | Q01726 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045703 | 1.00 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL4045701 | 1.00 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL13068821 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL4049528 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL2669494 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL4049534 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL14627481 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL18433159 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL14541435 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R | |
| SCHEMBL4049536 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RNAMPTMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409468-B9 | GUANIDINOBENZAMIDES AS MC4-R AGONISTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1409468-B1 | GUANIDINOBENZAMIDES AS MC4-R AGONISTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-11-12 | — | — | EP | disclosed |