Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566689 | 0.92 | MCHR1 (0.54) | MCHR1NR1H2ESR2 | |
| SCHEMBL1364854 | 0.89 | MCHR1 (0.54) | MCHR1ESR2 | |
| SCHEMBL1367875 | 0.85 | MCHR1 (0.52) | MCHR1NR1H2ESR2TMEM97SIGMAR1 | |
| SCHEMBL4046203 | 0.83 | NR1H2 (0.46) | MCHR1NR1H2ESR2TMEM97SIGMAR1 | |
| SCHEMBL30199590 | 0.82 | NR1H2 (0.60) | NR1H2ESR2TMEM97SIGMAR1HRH1 | |
| SCHEMBL1365643 | 0.81 | MCHR1 (0.52) | MCHR1NR1H2ESR2TMEM97SIGMAR1 | |
| SCHEMBL4046615 | 0.81 | MCHR1 (0.58) | MCHR1 | |
| SCHEMBL4047945 | 0.81 | MCHR1 (0.58) | MCHR1MAPK14 | |
| SCHEMBL1366972 | 0.79 | MCHR1 (0.54) | MCHR1ESR2MAPK14 | |
| SCHEMBL23684926 | 0.78 | ESR2 (0.64) | NR1H2ESR2TMEM97SIGMAR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |