Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13749116 | 0.83 | HRH3 (0.54) | MAPK14MCHR1CYP3A4 | |
| SCHEMBL4050118 | 0.82 | MCHR1 (0.43) | MCHR1 | |
| SCHEMBL4225814 | 0.82 | MCHR1 (0.46) | MCHR1 | |
| SCHEMBL1365814 | 0.82 | MCHR1 (0.58) | MAPK14MCHR1CYP3A4 | |
| SCHEMBL1365006 | 0.79 | MCHR1 (0.59) | MAPK14MCHR1 | |
| SCHEMBL4045071 | 0.79 | MCHR1 (0.48) | MAPK14MCHR1CYP3A4 | |
| SCHEMBL1364989 | 0.78 | MCHR1 (0.58) | MAPK14MCHR1CYP3A4 | |
| SCHEMBL4046203 | 0.77 | NR1H2 (0.46) | MAPK14MCHR1 | |
| SCHEMBL1367750 | 0.76 | MCHR1 (0.59) | MAPK14MCHR1 | |
| SCHEMBL29474892 | 0.75 | HRH3 (0.59) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |