Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 1.00 |
| ▸ | AR | P10275 | 4/20 | 0.75 |
| ▸ | MAOB | P27338 | 2/20 | 0.75 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046466 | 1.00 | NR1H4 (1.00) | NR1H4ARMAOBCHRNA7MEN1 | |
| SCHEMBL633204 | 0.91 | NR1H4 (0.83) | NR1H4ARMAOBCHRNA7MEN1 | |
| SCHEMBL331296 | 0.91 | NR1H4 (0.83) | NR1H4ARMAOBCHRNA7MEN1 | |
| SCHEMBL9112544 | 0.90 | NR1H4 (0.82) | NR1H4ARMAOBMAPTNPC1 | |
| SCHEMBL634206 | 0.88 | NR1H4 (0.79) | NR1H4ARMAOBCHRNA7MEN1 | |
| SCHEMBL634205 | 0.88 | NR1H4 (0.79) | NR1H4ARMAOBCHRNA7MEN1 | |
| SCHEMBL5084274 | 0.86 | AR (1.00) | NR1H4ARMAOBMEN1KMT2A | |
| SCHEMBL5084268 | 0.86 | AR (1.00) | NR1H4ARMAOBMEN1KMT2A | |
| SCHEMBL30807180 | 0.86 | AR (1.00) | NR1H4ARMAOBMEN1KMT2A | |
| SCHEMBL31238027 | 0.84 | CAPN1 (0.73) | NR1H4ARMAOBCHRNA7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| WO-2009026658-A1 | PPAR AGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009026658-A1 | PPAR AGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2009-03-05 | — | — | WO | disclosed |