Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.72 |
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | SLC29A2 | Q14542 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780526 | 0.87 | FLT3 (0.62) | FLT3BACE1AXLKITIRAK4 | |
| SCHEMBL4039143 | 0.86 | FLT3 (0.80) | FLT3BACE1AXLKITIRAK4 | |
| SCHEMBL4044001 | 0.84 | FLT3 (1.00) | FLT3BACE1AXLKITIRAK4 | |
| SCHEMBL2088273 | 0.82 | FLT3 (0.67) | FLT3BACE1AXLKITIRAK4 | |
| SCHEMBL4040306 | 0.79 | AXL (0.76) | FLT3AXLKITIRAK4AURKA | |
| SCHEMBL28335490 | 0.78 | FLT3 (0.61) | FLT3BACE1AXLKITAURKA | |
| SCHEMBL4036286 | 0.76 | FLT3 (0.64) | FLT3AXLKITIRAK4AURKA | |
| SCHEMBL2088150 | 0.76 | FLT3 (0.63) | FLT3BACE1AXLKITIRAK4 | |
| SCHEMBL3963633 | 0.75 | FLT3 (0.61) | FLT3BACE1AXLKITAURKA | |
| SCHEMBL4043057 | 0.75 | BACE1 (0.58) | FLT3BACE1AXLKITIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |