Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177672 | 0.81 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL7753102 | 0.81 | KCNA5 (0.50) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL28858566 | 0.81 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL21742037 | 0.78 | TSHR (0.46) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL8317919 | 0.78 | HRH1 (0.42) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL27855629 | 0.78 | KCNA5 (0.51) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL5762415 | 0.77 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL5762413 | 0.77 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL10938888 | 0.77 | KCNA5 (0.50) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 | |
| SCHEMBL5763081 | 0.77 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106518757-B | A kind of method that microwave method synthesizes the halogenated -3- substituted hydrocarbon radical sulfonyl pyridine of 2- and its intermediate | 山东师范大学 | 2019-03-19 | — | — | CN | disclosed |
| CN-103694122-B | One 2,2 ', 4,4 ', 6, the preparation method of 6 '-picryl sulfide base ethene | XI'AN INST. OF MODERN CHEMISTRY (CN) | 2016-05-25 | — | — | CN | disclosed |
| US-7560474-B2 | Derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them | LEK PHARMACEUTICALS D.D. (SI) | 2009-07-14 | — | — | US | disclosed |
| US-20050256172-A1 | Novel derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them | LEK PHARMACEUTICALS D.D. (SI) | 2005-11-17 | — | — | US | disclosed |
| CN-1668594-A | New derivatives of pyridylethanol (phenylethyl) amines useful as cholesterol biosynthesis inhibitors, process for their preparation and pharmaceutical compositions containing them | LEK FARMACEVTSKA DRUZBA DD (SI) | 2005-09-14 | — | — | CN | disclosed |
| EP-1546105-A1 | NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Lek Pharmaceutical and Chemical Co. D.D. (SI) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007456-A1 | NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LEK PHARMACEUTICALS D.D. (SI) | 2004-01-22 | — | — | WO | disclosed |
| US-5691053-A | Coating composition with thermally-influenced color | DAIMLER-BENZ AG (DE) | 1997-11-25 | — | — | US | disclosed |
| EP-0691979-A1 | NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM | SANOFI (FR) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022890-A1 | NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM | STERLING WINTHOP INC. (US) | 1994-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256172-A1 | Novel derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them | DHCR7, NR1H3, NR1H4 | SLC6A2 1063/4885SLC6A4 1772/4885SLC6A3 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.