Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168285 | 0.84 | CYP8B1 (0.49) | CYP8B1HRH4HRH3CYP2C19PIK3CA | |
| SCHEMBL13527137 | 0.80 | CYP8B1 (0.47) | CYP8B1HRH4HRH3CYP2C19PIK3CA | |
| SCHEMBL3167861 | 0.78 | CYP8B1 (0.49) | CYP8B1SLC2A1KCNH2 | |
| SCHEMBL5905803 | 0.75 | CYP8B1 (0.50) | CYP8B1CYP2C19PIK3CASLC2A1KCNH2 | |
| SCHEMBL3162808 | 0.75 | CYP8B1 (0.49) | CYP8B1CYP2C19PIK3CASLC2A1KCNH2 | |
| SCHEMBL3177584 | 0.74 | MAP4K4 (0.52) | CYP8B1CYP2C19PIK3CAKCNH2 | |
| SCHEMBL3162840 | 0.73 | CYP8B1 (0.47) | CYP8B1HRH4HRH3CYP2C19PIK3CA | |
| SCHEMBL4071024 | 0.73 | CYP8B1 (0.45) | CYP8B1CYP2C19KCNH2 | |
| SCHEMBL1224565 | 0.72 | CYP8B1 (0.53) | CYP8B1CYP2C19PIK3CAKCNH2 | |
| SCHEMBL10078646 | 0.72 | CYP8B1 (0.53) | CYP8B1CYP2C19PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773343-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| EP-1773343-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017326-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |