Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.75 |
| ▸ | PDE4A | P27815 | 8/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046368 | 0.92 | PDE4B (0.78) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4048564 | 0.89 | PDE4B (0.75) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4052891 | 0.88 | PDE4B (0.82) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4046711 | 0.86 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4047643 | 0.84 | PDE4B (0.71) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL5242434 | 0.84 | PDE4B (0.74) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4052957 | 0.84 | PDE4B (0.72) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4050117 | 0.80 | PDE4B (0.78) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4052264 | 0.79 | PDE4B (0.73) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4050675 | 0.76 | PDE4B (0.61) | PDE4BPDE4APDE4DKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | claimed |