Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051247 | 0.85 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL29829004 | 0.79 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL15206385 | 0.79 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL15206460 | 0.79 | PIK3CA (0.45) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL300848 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CAHTT | |
| SCHEMBL28029223 | 0.78 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAHTT | |
| SCHEMBL15205609 | 0.78 | PIK3CA (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL15206785 | 0.78 | KDM4E (0.41) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL29829049 | 0.77 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 | |
| SCHEMBL15205774 | 0.77 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CGPIK3CAMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |