Tirapazamine

Tirapazamine

SCHEMBL4048

Nc1n[n+]([O-])c2ccccc2[n+]1[O-]

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
BCL2 P10415 1/20 0.38
ATM Q13315 1/20 0.37
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
CASP6 P55212 1/20 0.36
KMT2A Q03164 1/20 0.36
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tirapazamine SCHEMBL29360622 1.00 CA12 (0.39) CA12CA1CA2CA9BCL2
Tirapazamine SCHEMBL28865429 0.85 CA12 (0.33) CA12CA1CA2CA9BCL2
Tirapazamine SCHEMBL28856314 0.83 CA12 (0.32) CA12CA1CA2CA9BCL2
SCHEMBL19235741 0.79 MEN1 (0.38) BCL2ATMMEN1POLBCASP6
SCHEMBL1695948 0.79 CA12 (0.32) CA12CA1CA2CA9ATM
SCHEMBL15024662 0.75 BACE1 (0.32) MEN1KMT2A
SCHEMBL2775458 0.75 TSHR (0.33)
SCHEMBL15008539 0.74 ATM (0.37) CA12CA1CA2CA9BCL2
SCHEMBL13084389 0.74 ATM (0.37) CA12CA1CA2CA9BCL2
SCHEMBL6084998 0.74 MEN1 (0.45) CA12CA1CA2CA9BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21131 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
CN-121466351-B Composite nano gel and preparation method and application thereof 华中科技大学同济医学院附属协和医院 2026-05-15 CN claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
EP-4732908-A2 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS Biomed Valley Discoveries, Inc. (US) 2026-04-29 EP claimed
US-20260091119-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA CELLIS AG (CH) 2026-04-02 US claimed
US-12570704-B2 Functionally modified maytansinoids and compositions and methods of use thereof University of Georgie Research Foundation, Inc. (US) 2026-03-10 US claimed
EP-4043017-B1 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2026-01-28 EP claimed
EP-4676551-A1 RADIATION SPACER HYDROGELS, METHODS OF FORMING, AND METHODS OF USE Clearstream Technologies Limited (IE) 2026-01-14 EP claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250367471-A1 PERFUSION MODULATED TUMOR DOSE SCULPTING WITH SINGLE DOSE RADIOTHERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-12-04 US claimed
WO-1997011699-A1 1,2,4-BENZOTRIAZINE OXIDES FORMULATIONS SANOFI WINTHROP INC. (US) 1997-04-03 WO claimed
US-5616584-A ADMINISTERING A SENSITIZER PRIOR ANTITUMOR RADIATION THERAPY SRI INTERNATIONAL (US) 1997-04-01 US claimed
US-5484612-A Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1996-01-16 US claimed
EP-0649658-A1 Method of tumor treatment THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1995-04-26 EP claimed
US-5399363-A IV administration for insoluble medicaments EASTMAN KODAK COMPANY (US) 1995-03-21 US claimed
EP-0577215-A1 Surface modified anticancer nanoparticles NanoSystems L.L.C. (US) 1994-01-05 EP claimed
EP-0478545-A4 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS STANFORD RES INST INT (US) 1992-08-05 EP claimed
EP-0478545-A1 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS SRI INTERNATIONAL (US) 1992-04-08 EP claimed
WO-1991004028-A1 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS SRI INTERNATIONAL (US) 1991-04-04 WO claimed
US-4102840-A FORMALDEHYDE, ETHERIFICATION, CREASE RESISTANCE, SHRINK RESISTANCE CIBA-GEIGY CORPORATION (US) 1978-07-25 US claimed