Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 7/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | AOC2 | O75106 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CDK9 | P50750 | 3/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67119 | 0.83 | — | — | |
| SCHEMBL29602491 | 0.83 | — | — | |
| SCHEMBL492397 | 0.83 | — | — | |
| SCHEMBL1581621 | 0.82 | QPCT (0.34) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| SCHEMBL27982384 | 0.81 | KDM4A (0.53) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| Bromide SCHEMBL4711523 | 0.81 | KDM4A (0.53) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| Hydrochloric Acid SCHEMBL3810977 | 0.81 | PIM1 (0.36) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| Hydrochloric Acid SCHEMBL16162592 | 0.81 | KDM4A (0.53) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| SCHEMBL28675683 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL2308667 | 0.81 | KDM4A (0.53) | KDM4AKDM4BKDM5CKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018383-A1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | Pfizer Products Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007132308-A1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2007-11-22 | — | — | WO | disclosed |