SCHEMBL4048508

SCHEMBL4048508

COC(=O)Cn1ccc(OCc2ccccc2)cc1=O

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.65
MCHR1 Q99705 14/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7641512 0.88 MAPK14 (0.62) MAPK14MCHR1
SCHEMBL18913970 0.88 MAPK14 (0.62) MAPK14MCHR1
SCHEMBL4470849 0.87 MAPK14 (0.68) MAPK14MCHR1
SCHEMBL4045555 0.87 MAPK14 (0.72) MAPK14MCHR1
SCHEMBL7636901 0.85 MAPK14 (0.60) MAPK14MCHR1
SCHEMBL4489978 0.84 MAPK14 (0.68) MAPK14MCHR1
SCHEMBL4053036 0.83 MCHR1 (0.64) MAPK14MCHR1
SCHEMBL2006359 0.81 PPARD (0.58)
SCHEMBL4484736 0.81 MAPK14 (0.76) MAPK14MCHR1
SCHEMBL1365256 0.81 MAPK14 (0.67) MAPK14MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009103478-A1 PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-08-27 WO disclosed