Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.56 |
| ▸ | MTOR | P42345 | 12/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051494 | 0.91 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4051823 | 0.84 | PIK3CA (0.76) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL4049643 | 0.83 | PIK3CA (0.58) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL4057700 | 0.81 | HRH3 (0.58) | PIK3CAPIK3CGPIK3CDPIK3CBFLT3 | |
| SCHEMBL4053416 | 0.81 | MTOR (0.52) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL4053032 | 0.79 | MTOR (0.65) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL1113809 | 0.78 | PIK3CA (0.78) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL4050346 | 0.78 | PIK3CA (0.77) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL4111305 | 0.77 | PIK3CA (0.42) | PIK3CAMTORPIK3CGPIK3CDPRKDC | |
| SCHEMBL4050772 | 0.77 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | claimed |
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-10 | — | — | US | claimed |
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | MTOR, RICTOR, RPS6KA3 | PIK3CA 19/4885MTOR 1/4885PIK3CG 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.