SCHEMBL4048797

SCHEMBL4048797

BrCCc1cc[nH]n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2000341 0.86
SCHEMBL18543120 0.83 KCNH2 (0.31)
Hydrochloric Acid SCHEMBL17361360 0.82
Tert-Butyl Formate SCHEMBL28814213 0.81 TDP1 (0.41)
SCHEMBL4505350 0.81
SCHEMBL3346700 0.80
SCHEMBL26129787 0.80
SCHEMBL348083 0.79
SCHEMBL16763155 0.78 KCNH2 (0.35)
Betazole SCHEMBL157155 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101679414-A Non-nucleoside reverse transcriptase inhibitors HOFFMANN LA ROCHE 2010-03-24 CN disclosed
EP-1758585-A4 HIV INTEGRASE INHIBITORS MERCK & CO INC (US) 2009-07-22 EP disclosed
US-7476666-B2 HIV integrase inhibitors MERCK & CO., INC. (US) 2009-01-13 US disclosed
CN-101146540-A HIV integrase inhibitors MERCK & CO INC (US) 2008-03-19 CN disclosed
US-20080015187-A1 Hiv Integrase Inhibitors MERCK SHARP & DOHME CORP. 2008-01-17 US disclosed
EP-1758585-A2 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (US) 2007-03-07 EP disclosed
WO-2006051143-A8 HETEROCYCLIC LIGANDS AND THE GADOLINIUM (III) COMPLEXES THEREOF WITH BIOMEDICAL APPLICATIONS UNIV NAC DE EDUCACION A DISTAN (ES) 2006-11-23 WO disclosed
WO-2006051142-A1 1-PYRAZOLYLETHYL-1,4,7,10-TETRAAZACYCLODODECANE-4,7,10-TRIACETIC ACIDS AND APPLICATION OF THE GADOLINIUM (III) COMPLEXES THEREOF IN CLINICAL DIAGNOSIS UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA (U.N.E.D.) (ES) 2006-05-18 WO disclosed
WO-2006051143-A1 HETEROCYCLIC LIGANDS AND THE GADOLINIUM (III) COMPLEXES THEREOF WITH BIOMEDICAL APPLICATIONS UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA (U.N.E.D.) (ES) 2006-05-18 WO disclosed
WO-2005120516-A2 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2005-12-22 WO disclosed
US-4154844-A ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-15 US disclosed
US-4151288-A ANTHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-04-24 US disclosed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4137237-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4070475-A THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1978-01-24 US disclosed
US-4024271-A INHIBITORS OF HISTAMINE ACTIVITY SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-17 US disclosed
US-4022797-A PHARMACEUTICALS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-10 US disclosed
US-4018931-A INHIBITION OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-04-19 US disclosed
US-3950353-A HISTAMINE INHIBITORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed
US-3950333-A HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed