Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055498 | 0.90 | PIK3CA (0.50) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4059885 | 0.88 | PIK3CA (0.54) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4057772 | 0.86 | HDAC1 (0.48) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4056512 | 0.86 | PIK3CA (0.64) | MTORPIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4049973 | 0.84 | PIK3CA (0.48) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4050610 | 0.84 | MTOR (0.57) | MTORPIK3CAPIK3R1PIK3CGALDH1A1 | |
| SCHEMBL4053455 | 0.83 | MTOR (0.52) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4059089 | 0.83 | PIK3CA (0.50) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4049643 | 0.82 | PIK3CA (0.58) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4051175 | 0.80 | MTOR (0.56) | MTORPIK3CAPIK3R1PIK3CGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | claimed |
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-10 | — | — | US | claimed |
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227575-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | MTOR, RICTOR, RPS6KA3 | MTOR 1/4885PIK3CA 19/4885PIK3R1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.