Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048087 | 0.95 | PARP1 (0.69) | PARP1CYP1A2 | |
| SCHEMBL4049214 | 0.94 | PARP1 (0.68) | PARP1CYP1A2 | |
| SCHEMBL4046789 | 0.88 | PARP1 (0.66) | PARP1CYP1A2PARP2 | |
| SCHEMBL4054673 | 0.87 | PARP1 (0.67) | PARP1CYP1A2 | |
| SCHEMBL4047821 | 0.86 | PARP1 (0.65) | PARP1CYP1A2PARP2 | |
| SCHEMBL4051261 | 0.84 | PARP1 (0.71) | PARP1CYP1A2 | |
| SCHEMBL4054595 | 0.83 | PARP1 (0.70) | PARP1CYP1A2 | |
| SCHEMBL4052768 | 0.83 | PARP1 (0.69) | PARP1CYP1A2 | |
| SCHEMBL4046748 | 0.82 | PARP1 (0.69) | PARP1CYP1A2 | |
| SCHEMBL17200165 | 0.82 | PARP1 (0.69) | PARP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069351-A2 | PYRAZOLOQUINAZOLINONES AS PARP INHIBITORS | Abbott Laboratories (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2007149907-A2 | PYRAZOLOQUINAZOLINONES AS PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-12-27 | — | — | WO | disclosed |