⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3550320 | 0.83 | PDE4B (0.43) | — | |
| SCHEMBL1824926 | 0.73 | PDE4B (0.45) | — | |
| SCHEMBL4049749 | 0.73 | PDE4A (0.33) | — | |
| SCHEMBL673206 | 0.71 | PDE4B (0.54) | — | |
| SCHEMBL4049371 | 0.69 | PDE4A (0.35) | — | |
| SCHEMBL1823547 | 0.67 | PDE4A (0.43) | — | |
| SCHEMBL3558073 | 0.66 | PDE4A (0.45) | — | |
| SCHEMBL3530377 | 0.65 | PDE4B (0.47) | — | |
| SCHEMBL1143842 | 0.65 | TNF (0.40) | — | |
| SCHEMBL3552407 | 0.64 | PDE4A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511072-B2 | 7-amido-isoindolyl compounds and methods of its use | CELGENE CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070254942-A1 | 7-amido-isoindolyl compounds and methods of its use | CELGENE CORPORATION. | 2007-11-01 | — | — | US | disclosed |