Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 15/20 | 0.81 |
| ▸ | HTR2A | P28223 | 3/20 | 0.81 |
| ▸ | HTR2C | P28335 | 3/20 | 0.81 |
| ▸ | HTR2B | P41595 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051375 | 0.93 | HRH2 (0.76) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4051729 | 0.91 | HRH2 (0.74) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4057729 | 0.90 | HRH2 (1.00) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5348195 | 0.88 | HRH2 (0.74) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4053204 | 0.87 | HRH2 (0.80) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4054397 | 0.86 | HRH2 (0.74) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5343718 | 0.85 | HRH2 (0.73) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5350635 | 0.84 | HRH2 (0.78) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL6780104 | 0.84 | HRH2 (0.84) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5346744 | 0.84 | HRH2 (0.88) | HRH2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560471-B2 | 5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid; histamine H1 antagonists; bronchial dialtors; asthma; allergic rhinitis; conjunctivitis; dermatitis; urticaria; selective antiallergic effects so less side effect reduction and lower dosage | LABORATORIOS ALMIRALL S.A. (ES) | 2009-07-14 | — | — | US | claimed |
| US-20060094879-A1 | New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-05-04 | — | — | US | claimed |
| EP-1513826-B1 | NEW INDOLYLPIPERIDINE DERIVATIVES AS POTENT ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-01-25 | — | — | EP | claimed |
| US-7560471-B2 | 5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid; histamine H1 antagonists; bronchial dialtors; asthma; allergic rhinitis; conjunctivitis; dermatitis; urticaria; selective antiallergic effects so less side effect reduction and lower dosage | LABORATORIOS ALMIRALL S.A. (ES) | 2009-07-14 | — | — | US | disclosed |
| US-20060094879-A1 | New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-05-04 | — | — | US | disclosed |
| EP-1513826-B1 | NEW INDOLYLPIPERIDINE DERIVATIVES AS POTENT ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-01-25 | — | — | EP | disclosed |
| EP-1513826-A1 | NEW INDOLYLPIPERIDINE DERIVATIVES AS POTENT ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003099807-A1 | NEW INDOLYLPIPERIDINE DERIVATIVES AS POTENT ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094879-A1 | New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents | HRH2, HRH4, HRH1 | HRH2 1/4885HTR2A 18/4885HTR2C 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.