Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 20/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047861 | 0.80 | CHRM1 (1.00) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4051705 | 0.79 | CHRM1 (0.80) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4049862 | 0.75 | CHRM1 (1.00) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4052173 | 0.74 | CHRM1 (0.75) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4049507 | 0.74 | CHRM1 (0.74) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4053276 | 0.74 | CHRM1 (0.80) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4053586 | 0.73 | CHRM1 (1.00) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4225067 | 0.73 | CHRM1 (0.35) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4058554 | 0.73 | CHRM1 (0.81) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4051172 | 0.72 | CHRM1 (0.79) | CHRM1CHRM4CHRM5CHRM2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |