Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 16/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049553 | 1.00 | HSD17B3 (0.54) | HSD17B3MEN1KMT2AUSP2MAPK1 | |
| SCHEMBL4798279 | 0.91 | HSD17B3 (0.58) | HSD17B3ACHE | |
| SCHEMBL4798270 | 0.91 | HSD17B3 (0.58) | HSD17B3ACHE | |
| SCHEMBL14084479 | 0.90 | HSD17B3 (0.57) | HSD17B3KMT2AMAPK1 | |
| SCHEMBL14108038 | 0.89 | HSD17B3 (0.44) | HSD17B3SMN1; SMN2ACHE | |
| SCHEMBL4801463 | 0.87 | HSD17B3 (0.56) | HSD17B3DRD2DRD1 | |
| SCHEMBL4801450 | 0.87 | HSD17B3 (0.56) | HSD17B3DRD2DRD1 | |
| SCHEMBL4796974 | 0.84 | HSD17B3 (0.61) | HSD17B3 | |
| SCHEMBL4796961 | 0.84 | HSD17B3 (0.61) | HSD17B3 | |
| SCHEMBL4223294 | 0.83 | HSD17B3 (0.71) | HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720613-A4 | FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGERNASE 3 | BRISTOL MYERS SQUIBB CO (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1720613-A2 | FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGERNASE 3 | Bristol-Myers Squibb Company (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005084296-A2 | FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGERNASE 3 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-09-15 | — | — | WO | disclosed |