Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049588 | 0.95 | PHGDH (0.40) | PHGDHCCR5SMN1; SMN2PDE10AHTT | |
| SCHEMBL4055062 | 0.91 | ABCG2 (0.41) | SCN9APHGDHABCG2CCR5SMN1; SMN2 | |
| SCHEMBL4052879 | 0.70 | HTR2C (0.40) | SMN1; SMN2HTTPDE4BADORA1ADORA2A | |
| SCHEMBL4061317 | 0.69 | ABCG2 (0.54) | PHGDHABCG2PDE4BADORA1 | |
| SCHEMBL2830399 | 0.69 | PDE4B (0.53) | PDE4BADORA1ADORA2A | |
| SCHEMBL27674471 | 0.67 | PDE10A (0.39) | SCN9APHGDHABCG2PDE10AHTT | |
| SCHEMBL4053907 | 0.67 | MEN1 (0.40) | SMN1; SMN2HTTPDE4BPDE4APDE4C | |
| SCHEMBL14152218 | 0.66 | PHGDH (0.46) | PHGDHCCR5SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4051316 | 0.66 | MEN1 (0.41) | SMN1; SMN2HTTPDE4BPDE4APDE4C | |
| SCHEMBL4057130 | 0.65 | HTR2C (0.42) | PDE10AHTTPDE4BADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511038-B2 | Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors | LABORATORIOS ALMIRALL S.A. (ES) | 2009-03-31 | — | — | US | claimed |