Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 11/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16321603 | 0.82 | NPC1 (0.44) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL14237485 | 0.81 | IDO1 (0.48) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL4055463 | 0.81 | IDO1 (0.39) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL14693884 | 0.81 | IDO1 (0.53) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL16341406 | 0.78 | IDO1 (0.50) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL16320974 | 0.78 | IDO1 (0.36) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL16340838 | 0.78 | IDO1 (0.40) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL6046572 | 0.77 | PRKCI (0.38) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL12053689 | 0.76 | NPC1 (0.39) | NPC1RAB9APKMNFKB1NFKB2 | |
| SCHEMBL16340917 | 0.75 | IDO1 (0.35) | NPC1RAB9AIDO1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | claimed |