Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 10/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046562 | 0.92 | FYN (0.53) | PIM1PIM2FYN | |
| SCHEMBL3870154 | 0.86 | MKNK1 (0.47) | PIM1FYNDYRK3CCNT1CCNA2 | |
| SCHEMBL3865962 | 0.86 | MKNK1 (0.47) | PIM1FYNDYRK3CCNT1CCNA2 | |
| SCHEMBL3869751 | 0.85 | PIM1 (0.54) | PIM1DYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL3868540 | 0.85 | PIM1 (0.47) | PIM1FYNDYRK3CCNT1CCNA2 | |
| SCHEMBL3866313 | 0.84 | DYRK3 (0.45) | PIM1FYNDYRK3CCNT1CCNA2 | |
| SCHEMBL3866139 | 0.84 | PIM1 (0.50) | AKT1AKT2PIM1DYRK3CCNT1 | |
| SCHEMBL3865829 | 0.83 | PIM1 (0.59) | PIM1DYRK1A | |
| SCHEMBL3867064 | 0.83 | MKNK1 (0.42) | PIM1FYNDYRK3CCNT1CCNA2 | |
| SCHEMBL3868645 | 0.81 | MKNK1 (0.42) | PIM1FYNDYRK3CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044071-A1 | OOXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147646-A1 | OXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |