Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.44 |
| ▸ | CNR2 | P34972 | 7/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13691001 | 1.00 | CNR1 (0.44) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL4049829 | 0.91 | ROCK1 (0.43) | CNR1CNR2KDM4CROCK1 | |
| SCHEMBL13690962 | 0.91 | ROCK1 (0.43) | CNR1CNR2KDM4CROCK1 | |
| SCHEMBL4056764 | 0.90 | CNR1 (0.49) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL13690992 | 0.90 | CNR1 (0.49) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL4056771 | 0.89 | CNR1 (0.41) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL13690996 | 0.89 | CNR1 (0.41) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL13690953 | 0.89 | CNR1 (0.41) | CNR1CNR2NR3C1KDM4CROCK1 | |
| SCHEMBL4048720 | 0.89 | CNR1 (0.56) | CNR1CNR2ROCK1HTR4CYP3A4 | |
| SCHEMBL4051703 | 0.88 | CNR1 (0.40) | CNR1CNR2NR3C1KDM4CROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |