Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 9/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170805 | 0.88 | TAAR1 (0.73) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3164851 | 0.88 | TAAR1 (0.72) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3161169 | 0.85 | TAAR1 (0.74) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3171735 | 0.81 | TAAR1 (0.73) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3162944 | 0.77 | TAAR1 (1.00) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3155735 | 0.74 | TAAR1 (0.70) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3161497 | 0.74 | TAAR1 (0.74) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3162891 | 0.74 | TAAR1 (0.69) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3164555 | 0.74 | TAAR1 (0.70) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL3165315 | 0.74 | TAAR1 (0.65) | TAAR1CYP2D6TSHRLMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076496-A1 | AMINOMETHYL-2-IMIDAZOLES WITH AFFINITY WITH THE TRACE AMINE ASSOCIATED RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | claimed |
| WO-2008046756-A1 | AMINOMETHYL-2-IMIDAZOLES WITH AFFINITY WITH THE TRACE AMINE ASSOCIATED RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2076496-A1 | AMINOMETHYL-2-IMIDAZOLES WITH AFFINITY WITH THE TRACE AMINE ASSOCIATED RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008046756-A1 | AMINOMETHYL-2-IMIDAZOLES WITH AFFINITY WITH THE TRACE AMINE ASSOCIATED RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |