Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.83 |
| ▸ | TTK | P33981 | 7/20 | 0.83 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.83 |
| ▸ | INSR | P06213 | 3/20 | 0.83 |
| ▸ | GAK | O14976 | 1/20 | 0.83 |
| ▸ | IGF1R | P08069 | 1/20 | 0.83 |
| ▸ | INSRR | P14616 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | LTK | P29376 | 1/20 | 0.83 |
| ▸ | CLK1 | P49759 | 1/20 | 0.83 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.83 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.83 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.83 |
| ▸ | NPM1 | P06748 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051438 | 0.92 | ALK (0.84) | ALKTTKPTK2INSRGAK | |
| SCHEMBL29446184 | 0.91 | ALK (1.00) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4051419 | 0.91 | ALK (1.00) | ALKTTKPTK2INSRGAK | |
| SCHEMBL29446147 | 0.91 | ALK (1.00) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4052384 | 0.90 | ALK (0.87) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4052581 | 0.88 | ALK (0.80) | ALKTTKPTK2INSRGAK | |
| SCHEMBL17731736 | 0.87 | TTK (1.00) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4050498 | 0.87 | ALK (0.81) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4056762 | 0.86 | ALK (0.85) | ALKTTKPTK2INSRGAK | |
| SCHEMBL4058870 | 0.85 | ALK (0.89) | ALKTTKPTK2INSRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | claimed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |