⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28312439 | 0.98 | — | — | |
| SCHEMBL27563605 | 0.70 | — | — | |
| SCHEMBL1231009 | 0.70 | — | — | |
| SCHEMBL27488323 | 0.68 | — | — | |
| SCHEMBL11597698 | 0.67 | — | — | |
| SCHEMBL7320440 | 0.67 | — | — | |
| SCHEMBL486333 | 0.62 | — | — | |
| SCHEMBL17866588 | 0.62 | KDM4E (0.46) | — | |
| SCHEMBL6827704 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL27083191 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461326-A | Novel substituted N' -hydroxycarbamimidoyl-1, 2, 5-oxadiazole compounds as indoleamine 2, 3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME | 2019-11-15 | — | — | CN | claimed |
| CN-106687450-B | A kind of indoles amine -2,3- dioxygenase inhibitor and preparation method thereof | 中国科学院上海有机化学研究所 | 2019-08-16 | — | — | CN | claimed |
| CN-109897011-A | A kind of IDO inhibitor and its application | 上海华汇拓医药科技有限公司 | 2019-06-18 | — | — | CN | claimed |
| EP-3389783-B1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| CN-109422739-B | Deuterated indoleamine 2, 3-dioxygenase inhibitor and application thereof | 药捷安康(南京)科技股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-110461326-A | Novel substituted N' -hydroxycarbamimidoyl-1, 2, 5-oxadiazole compounds as indoleamine 2, 3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME | 2019-11-15 | — | — | CN | disclosed |
| CN-110381963-A | It is related to the immunotherapy method and composition of tryptophan metabolic pathway regulator | 朱诺治疗学股份有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110357831-A | A kind of crystal form and its salt of IDO inhibitor | 江苏恒瑞医药股份有限公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-110343098-A | A kind of furodiazole compound and preparation method thereof, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2019-10-18 | — | — | CN | disclosed |
| EP-3544965-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE | Shanghai Fochon Pharmaceutical Co., Ltd. (CN) | 2019-10-02 | — | — | EP | disclosed |
| CN-110248931-A | A kind of salt of dioxygenase inhibitor and its preparation method and application | 上海翰森生物医药科技有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-108727361-A | Indole amine 2,3-dioxygenase inhibitor and application | 南京药捷安康生物科技有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-108473449-A | Sulfonamidine as indoleamine-2, 3-dioxygenase inhibitor and preparation method and application thereof | 上海长森药业有限公司 | 2018-08-31 | — | — | CN | disclosed |
| WO-2018095432-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2018-05-31 | — | — | WO | disclosed |
| CN-107954999-A | Han oxadiazole rings compound, preparation method, intermediate, composition and application | 上海医药集团股份有限公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-107033097-A | Oxadiazole analog derivative, its preparation method and its in application pharmaceutically | 江苏恒瑞医药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-106565696-A | Oxadiazole derivative, preparing method of oxadiazole derivative and application of oxadiazole derivative to medicines | 江苏恒瑞医药股份有限公司 | 2017-04-19 | — | — | CN | disclosed |
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | disclosed |