Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052463 | 0.94 | ALK (0.48) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL4051444 | 0.93 | ALK (0.55) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL13906274 | 0.92 | ALK (0.56) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL3956410 | 0.91 | ZAP70 (0.53) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL13906312 | 0.89 | LRRK2 (0.59) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL4048691 | 0.88 | ALK (0.55) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL3953268 | 0.87 | ALK (0.55) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL3956400 | 0.87 | ALK (0.62) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL3956401 | 0.86 | ZAP70 (0.52) | LRRK2ALKINSRIGF1RMAPK7 | |
| SCHEMBL18018900 | 0.85 | MAPK7 (0.55) | LRRK2ALKINSRIGF1RMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | claimed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |