Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.39 |
| ▸ | IKBKB | O14920 | 5/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868645 | 0.86 | MKNK1 (0.42) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3869120 | 0.86 | MKNK1 (0.42) | MKNK1IKBKBFLT3DYRK3DYRK1A | |
| SCHEMBL3872000 | 0.86 | FYN (0.43) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3865962 | 0.85 | MKNK1 (0.47) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3868140 | 0.84 | MKNK1 (0.41) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3865838 | 0.83 | PIM1 (0.41) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3866139 | 0.83 | PIM1 (0.50) | MKNK1DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL3871648 | 0.83 | IKBKB (0.40) | MKNK1IKBKBFYNDYRK3DYRK1A | |
| SCHEMBL3864200 | 0.82 | PIM1 (0.46) | DYRK3DYRK1ADYRK2DYRK1BCCNA2 | |
| SCHEMBL3871531 | 0.81 | MKNK1 (0.42) | MKNK1IKBKBDYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044071-A1 | OOXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147646-A1 | OXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |