Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062388 | 0.96 | SLC6A2 (0.63) | SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4947127 | 0.95 | SLC6A2 (0.61) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4052618 | 0.90 | SLC6A2 (0.56) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4944889 | 0.89 | SLC6A2 (0.51) | SLC6A2SLC6A3SLC6A4 | |
| Bicarbonate SCHEMBL4055846 | 0.89 | SLC6A2 (0.57) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4060782 | 0.88 | SLC6A2 (0.70) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4062392 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4061553 | 0.85 | SLC6A2 (0.57) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4056088 | 0.85 | SLC6A2 (0.70) | SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4947134 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |