Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.58 |
| ▸ | HTR3A | P46098 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578703 | 0.93 | HRH3 (0.56) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL14303754 | 0.89 | HRH3 (0.51) | HRH3HTR3AKCNH2 | |
| SCHEMBL3576247 | 0.89 | HRH3 (0.51) | HRH3HTR3AKCNH2 | |
| SCHEMBL3582479 | 0.89 | HRH3 (0.55) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL3570912 | 0.87 | HRH3 (0.54) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL3581652 | 0.86 | HRH3 (0.56) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL3573815 | 0.85 | HRH3 (0.50) | HRH3HTR3AKCNH2 | |
| SCHEMBL3584189 | 0.85 | HRH3 (0.57) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL3582416 | 0.84 | HRH3 (0.57) | HRH3HTR3AKCNH2CHRM2SLC6A2 | |
| SCHEMBL3575983 | 0.84 | HRH3 (0.54) | HRH3HTR3AKCNH2CHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049548-A1 | FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS | UCB Pharma, S.A. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012010-A1 | FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS | UCB PHARMA, S.A. (BE) | 2008-01-31 | — | — | WO | disclosed |