Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | KHK | P50053 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375940 | 0.71 | HRH3 (0.55) | HRH3CHRM2HRH1KHKCD274 | |
| SCHEMBL18319037 | 0.66 | ACVR1 (0.49) | HRH3CHRM2HRH1KHKKCNH2 | |
| SCHEMBL5449252 | 0.65 | CD274 (0.47) | CD274PDCD1ACVR1FLT3GSK3B | |
| SCHEMBL1375220 | 0.65 | HRH3 (0.56) | HRH3HRH1KCNH2ROCK1 | |
| SCHEMBL5204218 | 0.65 | HRH1 (0.79) | HRH3HRH1KHKKCNH2ROCK1 | |
| SCHEMBL2019376 | 0.64 | HRH1 (0.70) | HRH3HRH1KHKKCNH2ACVR1B | |
| SCHEMBL1375829 | 0.62 | HRH3 (0.69) | HRH3HRH1KCNH2ACVR1BTGFBR1 | |
| Hydrochloric Acid SCHEMBL23410284 | 0.62 | HRH1 (0.61) | HRH3HRH1KHKKCNH2ACVR1B | |
| SCHEMBL18318800 | 0.62 | HRH1 (0.47) | HRH3HRH1KHKKCNH2ACVR1B | |
| SCHEMBL18318864 | 0.62 | ACVR1B (0.47) | HRH3HRH1KCNH2ACVR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |