Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569692 | 0.74 | HTT (0.41) | PDGFRBPDGFRAPOLBKMT2A | |
| SCHEMBL10994055 | 0.71 | CYP1A2 (0.38) | PDGFRBPDGFRAPOLBTDP1SIRT2 | |
| SCHEMBL3956168 | 0.70 | KDM4E (0.35) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL28511107 | 0.70 | PDGFRB (0.42) | PDGFRBPDGFRAKMT2A | |
| SCHEMBL9972594 | 0.69 | KMT2A (0.42) | PDE10APDE2APDGFRBPDGFRAPOLB | |
| SCHEMBL16751340 | 0.69 | PDE10A (0.46) | PDE10APDE2APOLBTDP1SIRT2 | |
| SCHEMBL30406083 | 0.68 | PDGFRB (0.47) | PDE10APDE2APDGFRBPDGFRAPOLB | |
| SCHEMBL622722 | 0.68 | PDGFRB (0.47) | PDE10APDE2APDGFRBPDGFRAPOLB | |
| SCHEMBL20563409 | 0.67 | KMT2A (0.37) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL23084868 | 0.66 | KCNH2 (0.44) | PDE10APDE2APDGFRBPDGFRAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004032856-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | claimed |
| EP-1773343-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| EP-1846411-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-10-24 | — | — | EP | disclosed |
| EP-1773343-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006081289-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006017326-A1 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |
| WO-2004032856-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | disclosed |