Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ezogabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 known ✓ | O43526 | 8/20 | 1.00 |
| ▸ | KCNQ3 known ✓ | O43525 | 6/20 | 1.00 |
| ▸ | KCNQ4 known ✓ | P56696 | 6/20 | 1.00 |
| ▸ | KCNQ5 known ✓ | Q9NR82 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ezogabine SCHEMBL20835 | 1.00 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL29359156 | 1.00 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL15357224 | 1.00 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL154715 | 0.99 | KCNQ2 (0.98) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL155918 | 0.99 | KCNQ2 (0.98) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL15539530 | 0.97 | KCNQ2 (0.94) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL3102203 | 0.93 | KCNQ2 (0.87) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL30824720 | 0.93 | KCNQ2 (0.87) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL28471969 | 0.93 | KCNQ2 (0.86) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL29754400 | 0.91 | KCNQ2 (0.83) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012769-A1 | POTASSIUM CHANNEL ACTIVATORS FOR THE PREVENTION AND TREATMENT OF DYSTONIA AND DYSTONIA-LIKE SYMPTOMS | Rundfeldt, Chris (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007128462-A1 | POTASSIUM CHANNEL ACTIVATORS FOR THE PREVENTION AND TREATMENT OF DYSTONIA AND DYSTONIA-LIKE SYMPTOMS | RUNDFELDT CHRIS (DE) | 2007-11-15 | — | — | WO | disclosed |